Patent Number: 6,253,168

Title: Generation of virtual combinatorial libraries of compounds

Abstract: The present invention provides methods for the generation of virtual libraries of compounds. These compounds are generated in silico. The present invention encompasses methods for tracking the addition of fragments, use of reagents, and transformations performed. Further, methods for interfacing the information necessary to generate libraries of compounds with instrumentation that conducts the actual synthesis of the compounds are provided. Also provided are methods for the in silico docking of the library compounds to identified target molecules of interest.

Inventors: Griffey; Richard (Vista, CA), Swayze; Eric (Carlsbad, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: G06G 7/48 (20060101); G06G 7/00 (20060101); G06G 7/58 (20060101); G06G 007/48 (); G06G 007/58 ()

Expiration Date: 06/26/2018