Patent Number: 6,254,861

Title: Hematopoietic growth factor derived from T lymphocytes

Abstract: A T cell-derived colony stimulating factor ("TC-CSF") may be isolated from media conditioned with T lymphocyte cells. TC-CSF stimulates formation of colonies composed of granulocytes, macrophages, megakaryocytes, fibrocytic stromal cells, lymphocytes, and mixed colonies of granulocytes and macrophages. Anion exchange chromatography may be employed in conjunction with gel filtration and rpHPLC to isolate TC-CSF. Human TC-CSF and murine TC-CSF cDNA, MRNA, genomic DNA nucleotide and amino acid sequences, expression products, pharmaceutical formulations and antibody materials are specifically provided.

Inventors: Choudhury; Chandra (New Orleans, LA)


International Classification: C07K 14/53 (20060101); C07K 14/435 (20060101); C07K 16/18 (20060101); C07K 16/24 (20060101); C12Q 1/68 (20060101); A61K 38/00 (20060101); A61K 045/00 (); A61K 038/00 (); C07K 014/00 (); A01N 037/18 ()

Expiration Date: 07/03/2018