Patent Number: 6,254,862

Title: Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof

Abstract: Adenovirus vectors replication specific for cells expressing .alpha.-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.

Inventors: Little; Andrew S. (Los Altos, CA), Henderson; Daniel R. (Palo Alto, CA), Schuur; Eric R. (Palo Alto, CA), Lamparski; Henry (San Mateo, CA)

Assignee: Calydon, Inc.

International Classification: C07K 14/005 (20060101); C07K 14/075 (20060101); C07K 14/435 (20060101); C07K 14/47 (20060101); C12N 15/63 (20060101); C12N 15/861 (20060101); A61K 38/00 (20060101); A61K 48/00 (20060101); A61K 048/00 (); C12N 015/861 (); C12N 005/10 (); C12N 015/63 ()

Expiration Date: 07/03/2018