Patent Number: 6,254,873

Title: Inactivated dengue virus vaccine

Abstract: An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable cells, purified and inactivated under conditions which destroy infectivity but preserve immunogenicity, a high level of which is demonstrated in animal models.

Inventors: Putnak; J. Robert (Silver Spring, MD), Eckels; Kenneth (Rockville, MD), Dubois; Doris R. (Wheaton, MD)

Assignee: The United States of America as represented by the Secretary of the Army

International Classification: A61K 39/12 (20060101); C12N 7/04 (20060101); C07K 014/18 (); C12N 007/04 ()

Expiration Date: 07/03/2018