Patent Number: 6,254,885

Title: Oral cyclosphorin formulations

Abstract: Improved oral cyclosporin formulations which have high bioavailability and are capable of admiration in hard capsules are provided. In the subject formations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formalations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno-suppressive therapy.

Inventors: Cho; Moo J. (Chapel Hill, NC), Levy; Ralph E. (Pleasanton, CA), Pouletty; Philippe J. (Atherton, CA)

Assignee: SangStat Medical Corporation

International Classification: A61K 38/12 (20060101); A61K 38/13 (20060101); A61K 9/10 (20060101); A61K 9/48 (20060101); A61K 47/26 (20060101); A61K 47/10 (20060101); A61K 47/14 (20060101); C02F 1/50 (20060101); A61K 009/10 (); A61K 009/48 ()

Expiration Date: 07/03/2018