Patent Number: 6,254,890

Title: Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids

Abstract: The present invention provides biodegradable polymer nanospheres capable of transporting and releasing therapeutic agents, specifically nucleic acids. In preferred embodiments, a sub-150 nm nanosphere is formed containing nucleic acids. Thereafter, the agent is released from the nanosphere. In one embodiment a biodegradable polymer nanosphere surface has attached to it a targeting moiety. In another embodiment, the biodegradable polymer nanosphere surface has attached to it a masking moiety. In yet another embodiment both targeting and masking moieties are attached to the nanosphere surface.

Inventors: Hirosue; Sachiko (Cambridge, MA), Mueller; Bernhard G. (Kaltbach, CH), Langer; Robert S. (Newton, MA), Mulligan; Richard C. (Lincoln, MA)

Assignee: Massachusetts Institute of Technology

International Classification: A61K 9/51 (20060101); A61K 009/51 (); A61K 009/52 (); A61K 009/64 (); A61K 009/58 ()

Expiration Date: 07/03/2018