Patent Number: 6,254,891

Title: Extended release acetaminophen

Abstract: An extended release acetaminophen composition comprises particles containing acetaminophen coated on sugar/starch seeds. The particles are present as a blend of both an immediate release and a controlled release form. The composition, when contained within a gelatin capsule and assayed in a USP Apparatus I rotating basket at 50 rpm in 900 mL of phosphate buffer at pH 5.8 and a temperature of C., exhibits about 40 percent acetaminophen dissolution at one-half hour, about 55 percent acetaminophen dissolution at one hour, and substantially complete dissolution of acetaminophen at six hours. A process for treating a human patient with the extended release acetaminophen composition is also disclosed.

Inventors: Anaebonam; Aloysius O. (Burlington, MA), Clemente; Emmett (Manchester, MA), Mendes; Robert W. (Dedham, MA)

Assignee: Ascent Pediatrics, Inc.

International Classification: A61K 9/16 (20060101); A61K 9/50 (20060101); A61K 009/16 (); A61K 009/50 ()

Expiration Date: 07/03/2018