Patent Number: 6,254,986

Title: Peracylated protein-based sutures and fabrics and process for making the same

Abstract: A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl groups. Most preferably, the cyclic anhydride is succinic anhydride, although glutaric anhydride may also be employed. Preferably, the step of peracylating the protein or polypeptide is performed in the presence of an acid catalyst, most preferably .rho.-toluene sulfonic acid. The resultant modified protein or polypeptide may be employed in numerous applications including drug delivery, absorbable sutures, and thermoplastic films and molded articles.

Inventors: Shalaby; Shalaby W. (Anderson, SC), Allan; Jacqueline M. (Newtown, PA), Corbett; Joel T. (Camden, SC)

Assignee: Poly-Med, Inc.

International Classification: C07K 1/00 (20060101); C07K 1/113 (20060101); C07K 14/415 (20060101); D02G 003/00 (); C07K 001/00 ()

Expiration Date: 07/03/2018