Patent Number: 6,255,111

Title: Antisense modulation of Her-4 expression

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Her-4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-4. Methods of using these compounds for modulation of Her-4 expression and for treatment of diseases associated with expression of Her-4 are provided.

Inventors: Bennett; C. Frank (Carlsbad, CA), Cowsert; Lex M. (Carlsbad, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: C12N 15/11 (20060101); A61K 38/00 (20060101); C07H 021/04 (); C07H 021/02 (); C12Q 001/68 ()

Expiration Date: 07/03/2018