Patent Number: 6,255,284

Title: Pharmaceutical composition

Abstract: Polypeptide pharmaceutical compositions having improved stability and resistance to aggregation, particle formation and precipitation comprising a polypeptide pharmaceutical and poloxamer surfactants alone, or in combination with polysorbate surfactants. Preferred polypeptides stabilized are bactericidal/permeability increasing (BPI) protein, biologically active fragments of BPI, biologically active analogs of BPI, and biologically active variants of BPI.

Inventors: McGregor; Weldon Courtney (Los Angeles, CA), Stubstad; James (Lafayette, CA), Chang; C. Paul (Chatsworth, CA)

Assignee: Xoma Corporation

International Classification: A61K 38/17 (20060101); A61K 47/26 (20060101); A61K 47/10 (20060101); A61K 035/14 ()

Expiration Date: 07/03/2018