Patent Number: 6,255,289

Title: Gene delivery by secretory gland expression

Abstract: Secretory gland cells, particularly pancreatic and salivary gland cells, are genetically altered to operatively incorporate a gene which expresses a protein which has a desired therapeutic effect on a mammalian subject. The expressed protein is secreted directly into the gastrointestinal tract and/or blood stream to obtain therapeutic blood levels of the protein thereby treating the patient in need of the protein. The transformed secretory gland cells provide long term therapeutic cures for diseases associated with a deficiency in a particular protein or which are amenable to treatment by overexpression of a protein.

Inventors: German; Michael (San Francisco, CA), Goldfine; Ira D. (Kentfield, CA), Rothman; Stephen S. (Berkeley, CA)

Assignee: The Regents of the University of California

International Classification: A61K 38/17 (20060101); A61K 38/18 (20060101); A61K 38/28 (20060101); A61K 38/36 (20060101); A61K 38/27 (20060101); A61K 38/37 (20060101); A61K 48/00 (20060101); A61K 048/00 ()

Expiration Date: 07/03/2018