Patent Number: 6,255,295

Title: Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue

Abstract: A composition for the protection, treatment and repair and for reducing the inflammation of connective tissue in mammals and a method for the protection, treatment of connective tissue in mammals by the administration of the composition. The composition includes at least two compounds selected from S-Adenosylmethionine (SAM), an aminosugar selected from the group consisting of glucosamine, glucosamine salts, glucosamine hydrochloride, galactosamine, N-acetylglucosamine, and fragments, mixtures or salts thereof, and a glycosaminoglycan or glycosaminoglycan-like compound selected from the group consisting of chondroitin, chondroitin salts, hyaluronic acid, glucuronic acid, iduronic acid, keratan sulfate, keratin sulfate, heparan sulfate, dermatin sulfate, PPS, sodium PPS, calcium PPS, oversulfated GAGs, and fragments, salts, and mixtures thereof. The composition optionally includes manganese which promotes the production of connective tissue matrix. The composition also optionally includes methyl donors or methyl donor cofactors, such as vitamin B.sub.12, vitamin B.sub.6, folic acid, dimethylglycine or trimethylglycine, and betaine.

Inventors: Henderson; Robert W. (Baldwin, MD), Henderson; Todd (Bel Air, MD), Hammad; Tarek (Baltimore, MD)

Assignee: Nutramax Laboratories, Inc.

International Classification: A61K 45/00 (20060101); A61K 45/06 (20060101); A61K 031/715 (); A61K 031/70 ()

Expiration Date: 07/03/2018