Patent Number: 6,255,300

Title: Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Abstract: The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH.sub.2 --O-- group. The compounds of the invention are represented by formula I: ##STR1## wherein A represent O, S or --CH.sub.2 -- attached at position 3, 4 or 6; Q is selected from the group consisting of: ##STR2## .alpha. represents O, S or NR.sup.s ; .beta., .delta., .gamma., .mu. and .sigma. represent CR.sup.t, N or N+R.sup.s, provided that no more than one of .beta., .delta., .gamma., .mu. and .sigma. is N+R.sup.s, balanced by L.sup.- or a carboxylate anion. Salts and hydrates thereof are included. The iodo-substituted phenyl ring is further substituted with various substituent groups including at least one cationic group. Pharmaceutical compositions and methods of treatment are also included.

Inventors: Dininno; Frank P. (Old Bridge, NJ), Dykstra; Kevin D. (West Milford, NJ)

Assignee: Merck & Co., Inc.

International Classification: C07D 477/14 (20060101); C07D 477/00 (20060101); C07D 477/14 (); A61K 031/419 (); A61K 031/417 (); A61K 031/407 (); A61P 031/04 ()

Expiration Date: 07/03/2018