Patent Number: 6,255,301

Title: Amino acid derivatives and their use as thrombin inhibitors

Abstract: There is provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

Inventors: Gustafsson; David (Kullavik, SE), Nystrom; Jan-Erik (Lindome, SE)

Assignee: AstraZeneca AB

International Classification: C07D 205/00 (20060101); C07D 401/00 (20060101); C07D 207/00 (20060101); C07D 401/12 (20060101); C07D 207/16 (20060101); C07D 205/04 (20060101); A61K 031/397 (); A61P 007/02 (); C07D 205/04 (); C07D 401/12 ()

Expiration Date: 07/03/2018