Patent Number: 6,255,305

Title: Substituted triazolo-pyridazine derivatives as ligands for GABA receptors

Abstract: Substituted triazolo-pyridazine derivative compounds represented by ##STR1## wherein the variables are disclosed herein are selective ligands for GABA-A receptors, particularly for the .alpha.2 and/or .alpha.3 subunits.

Inventors: Broughton; Howard Barff (Harlow, GB), Carling; William Robert (Bishops Stortford, GB), Castro Pineiro; Jose Luis (Bishops Stortford, GB), Guiblin; Alexander Richard (Welwyn Garden City, GB), Madin; Andrew (Sawbridgeworth, GB), Moore; Kevin William (Buntingford, GB), Russell; Michael Geoffrey (Welwyn Garden City, GB), Street; Leslie Joseph (Harlow, GB)

Assignee: Merck Sharp & Dohme Limited

International Classification: C07D 487/08 (20060101); C07D 487/00 (20060101); C07D 487/04 (20060101); A61K 037/502 (); C07D 487/04 (); C07D 487/14 ()

Expiration Date: 07/03/2018