Patent Number: 6,255,312

Title: Acyclic nucleoside derivatives

Abstract: Compounds of the Formula I ##STR1## where one of R.sub.1 and R.sub.2 is --C(O)CH(CH(CH.sub.3).sub.2)NH.sub.2 or --C(O)CH(CH(CH.sub.3)CH.sub.2 CH.sub.3)NH.sub.2 ; the other of R.sub.1 and R.sub.2 is --C(.dbd.O)C.sub.3 -C.sub.21 saturated or monounsaturated, optionally substituted alkyl; and R.sub.3 is OH or H; and pharmaceutically acceptable salts thereof have utility as enhanced bioavailability antivirals against herpes and retroviral infections.

Inventors: Engelhardt; Per (Stockholm, SE), Hogberg; Marita (Tullinge, SE), Johansson; Nils-Gunnar (Enhorna, SE), Zhou; Xiao-Xiong (Huddinge, SE), Lindborg; Bjorn (Bjornlunda, SE)

Assignee: Medivir AB

International Classification: C07D 473/18 (20060101); C07D 473/00 (20060101); A01N 043/90 ()

Expiration Date: 07/03/2018