Patent Number: 6,281,670

Title: Two-dimensional sensor having photoconductive layer for measuring cellactivity

Abstract: A two-dimensional sensor includes a photoconductive layer whoseconductivity increases at a light-irradiated spot, an insulating layerformed on the front surface of the photoconductive layer, an effectelectrode formed on the back surface of the photoconductive layer, and afence as a cell holder attached to the surface of the insulating layer forcontaining a cell, culture medium and a reference electrode. The sensor isplaced in an incubator and a bias voltage is applied between the effectand reference electrodes. When a laser beam irradiates a spot of the backsurface of the sensor, a signal is obtained from the effect electrode.This signal corresponds to a potential alteration due to the cell activitysubstantially at the laser-irradiated spot. The signal is processed in acomputer. The beam spot size and location, corresponding to the size andthe location of the measurement electrode, can be changed or adjustedeasily by focusing or moving the laser beam.

Inventors: Sugihara; Hirokazu (Katano, JP), Taketani; Makoto (Kyoto, JP), Kamei; Akihito (Nara, JP), Iwasaki; Hiroshi (Hirakata, JP)


International Classification: G01N 27/30 (20060101); G01N 33/487 (20060101); G01N 027/00 ()

Expiration Date: 08/28/2013