Patent Number: 6,294,648

Title: Protein having proteinase inhibitor activity

Abstract: BTL.009 is a novel human serine proteinase inhibitor of the Kunitz family that exhibits greater potency towards neutral serine proteinases, particularly leukocyte elastase, and chymotrypsin than towards trypsin-like proteinases. BTL.009, or variants thereof, may be employed as therapeutics in diseases such as emphysema, idiopathic pulmonary fibrosis, adult respiratory distress syndrome, cystic fibrosis, rheumatoid arthritis, organ failure, and glomerulonephritis in which uncontrolled proteolysis due to neutral serine proteinase activity results in tissue damage.

Inventors: Delaria; Kathy (Walnut Creek, CA), Roczniak; Steve (Lafayette, CA), Davies; Christopher (Walnut Creek, CA)

Assignee: Bayer Corporation

International Classification: C07K 14/81 (20060101); A61K 38/00 (20060101); A61K 038/00 ()

Expiration Date: 09/25/2018