Patent Number: 6,294,663

Title: Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof

Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.

Inventors: O'Brien; Timothy J. (Little Rock, AR), Underwood; Lowell J. (Little Rock, AR)

Assignee: The Board of Trustees of the University of Arkansas

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C07K 14/705 (20060101); C12N 9/64 (20060101); G01N 33/574 (20060101); A61K 39/00 (20060101); A61K 38/00 (20060101); A61K 48/00 (20060101); C12Q 1/68 (20060101); C07H 021/04 (); C12N 015/00 (); C12N 015/12 (); C12N 015/63 (); A61K 035/54 ()

Expiration Date: 09/25/2018