Patent Number: 6,294,669

Title: Crystalline substance of cefditoren pivoxyl and the production of the same

Abstract: As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated C. or below, to effect a complete crystallization of Cefditoren pivoxyl.

Inventors: Yasui; Kiyoshi (Odawara, JP), Onodera; Masahiro (Odawara, JP), Sukegawa; Masamichi (Odawara, JP), Watanabe; Tatsuo (Odawara, JP), Yamamoto; Yuichi (Motosu-gun, JP), Murai; Yasushi (Odawara, JP), Iinuma; Katsuharu (Odawara, JP)

Assignee: Meiji Seika Kaisha Ltd.

International Classification: C07D 501/00 (20060101); C07D 501/24 ()

Expiration Date: 09/25/2018