Patent Number: 6,294,672

Title: Indole and azaindole inhibitors of Fructose-1,6-biphosphatase

Abstract: The present invention is directed towards novel azaindole compounds which bind to the AMP site and are potent FBPase inhibitors. The present invention also is directed towards the clinical use of the novel FBPase inhibitors as a method of treatment or prevention of diseases responsive to lowered blood glucose levels.

Inventors: Reddy; K. Raja (San Diego, CA), Scarlato; Gerard R. (La Jolla, CA), Dang; Qun (San Diego, CA), Erion; Mark D. (Del Mar, CA), Kasibhatla; Srinivas Rao (San Diego, CA), Reddy; M. Rami (San Diego, CA)

Assignee: Metabasis Therapeutics, Inc.

International Classification: C07F 9/572 (20060101); C07F 9/00 (20060101); C07F 9/6561 (20060101); C07F 9/6558 (20060101); C07F 009/24 (); C07F 009/28 (); A61K 031/675 (); A61K 031/683 ()

Expiration Date: 09/25/2018