Patent Number: 6,294,674

Title: Dibenzofuran sulfonamide matrix metalloproteinase inhibitors

Abstract: The present invention relates to compounds of Formula I that inhibit matrix metalloproteinases and to a method of inhibiting matrix metalloproteinases using the compounds. ##STR1## wherein Q is an un-natural amino acid. More particurlarly, the present invention relates to a method of treating diseases in which matrix metalloproteinases are involved such as multiple sclerosis, atherosclerotic plaque rupture, restenosis, aortic aneurism, heart failure, periodontal disease, corneal ulceration, burns, decubital ulcers, chronic ulcers or wounds, cancer metastasis, tumor angiogenesis, arthiritis, or other autoimmune or inflammatory diseases dependent upon tissue invasion by leukocytes.

Inventors: Picard; Joseph Armand (Canton, MI), Sliskovic; Drago Robert (Saline, MI)

Assignee: Warner-Lambert Company

International Classification: C07D 307/00 (20060101); C07D 333/00 (20060101); C07D 307/91 (20060101); C07D 333/76 (20060101); C07D 307/91 (); C07D 405/12 (); C07D 409/12 ()

Expiration Date: 09/25/2018