Patent Number: 6,294,677

Title: Thiopyran derivatives

Abstract: An intermediate represented by the following formula (XVIII), ##STR1## wherein A is a sulfur atom or the group --CH.dbd.CH--; L is an alkylene group which may be substituted, an alkenylene group which may be substituted, or an alkynylene group which may be substituted; W represents a leaving group selected from the group consisting of a halogen atom, an alkyl sulfonyloxy group, and an aryl sulfonyloxy group, and Z represents the group; ##STR2## (wherein R.sub.1 is an alkyl group which may be substituted, an aromatic carbocyclic group which may be substituted, or an aralkyl group which may be substituted, X.sub.1, X.sub.2, and X.sub.3 individually represent an oxygen atom or a sulfur atom, and G represents an ethylene group or a trimethylene group, of which one or more hydrogen atoms of the ethylene group or trimethylene group may be replaced by a halogen atom, alkyl group, aromatic carbocyclic group, aralkyl group, or alkylidene group).

Inventors: Mizuno; Akira (Kyoto, JP), Shibata; Makoto (Ashikaga, JP), Iwamori; Tomoe (Ibaraki, JP), Inomata; Norio (Mino, JP)

Assignee: Suntory Limited

International Classification: C07D 335/00 (20060101); C07D 335/06 (20060101); C07D 495/04 (20060101); C07D 495/10 (20060101); C07D 495/00 (20060101); C07D 495/20 (20060101); C07D 335/06 (); C07D 495/10 (); C07D 497/10 (); C07D 409/06 (); A61K 031/496 ()

Expiration Date: 09/25/2018