Patent Number: 6,294,680

Title: Process for the production of semi synthetic statins via novel intermediates

Abstract: A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.

Inventors: Vries; Ton Rene (Groningen, NL), Wijnberg; Hans (Groningen, NL), Faber; Wijnand Sjourd (Groningen, NL), Kalkman-Agayn; Venetka Ivanova (Den Haag, NL), Sibeyn; Mieke Ivanova (Amersfoort, NL)

Assignee: Plus Chemicals, B.V.

International Classification: C07D 309/00 (20060101); C07D 309/30 (20060101); C07F 5/00 (20060101); C07F 5/02 (20060101); C07F 9/00 (20060101); C07F 9/6574 (20060101); C07D 319/06 (); C07D 411/00 ()

Expiration Date: 09/25/2018