Patent Number: 6,294,688

Title: Process useful to produce vitamin D analogs

Abstract: A stereospecific method for accomplishing the below reaction:##STR1##results in the compound of formula 2 having the same stereochemistry atboth carbon 1 and carbon 3 as that in the compound of formula 1. Thus, ifcarbon 3 is in the R-configuration in the compound of formula 1, thencarbon 3 will be in the R-configuration in the compound of resultingformula 2. In the above process, R.sup.1 is C.sub.1 -C.sub.6 alkyl thatcan be straight-chain or branched. The process functions using afluorinated alcohol having a pK.sub.a less than about 9, in the presenceof a palladium catalyst. The compounds of formula 1, as well as novelintermediates in this process, are useful in manufacturing vitamin Danalogs.

Inventors: Daniewski; Andrzej Robert (Bloomfield, NJ), Kabat; Marek Michal (Nutley, NJ), Okabe; Masami (Nutley, NJ), Radinov; Roumen Nikolaev (West Caldwell, NJ)


International Classification:

Expiration Date: 09/25/2013