Patent Number: 6,306,827

Title: Method for preventing and/or treating renal disease

Abstract: A preventative and/or therapeutic agent to treat and/or prevent organfailure due to mercury exposure, contains as the active ingredient amutant tumor cytotoxic factor protein (TCF-II). The therapeutic agentcomprises a mutant TCF-II protein according to SEQ ID NO. 2 in which aminoacid residues Arg-Lys-Arg-Arg have been replaced by Ala-Ala-Ala-Ala, or inwhich amino acids Lys-Ile-Lys-Thr-Lys-Lys have been replaced byAla-Ile-Ala-Thr-Ala-Ala (SEQ ID NO. 3).

Inventors: Kinosaki; Masahiko (Tochigi, JP), Ogawa; Hiromi (Tochigi, JP), Masunaga; Hiroaki (Tochigi, JP), Kobayashi; Fumie (Tochigi, JP), Yamaguchi; Kyoji (Saitama, JP), Higashio; Kanji (Saitama, JP)


International Classification:

Expiration Date: 10/23/2013