Patent Number: 6,307,101

Title: Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use

Abstract: Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.

Inventors: Campbell; David A. (San Mateo, CA), Patel; Dinesh V. (Fremont, CA), Xiao; Xiao-Yi (La Jolla, CA)


International Classification: C07C 323/00 (20060101); C07C 323/60 (20060101); C07K 5/072 (20060101); C07K 5/00 (20060101); C07K 5/06 (20060101); C07C 233/00 (); C07C 235/00 (); C07C 237/00 (); C07C 239/00 (); C07C 321/00 ()

Expiration Date: 10/23/2018