Patent Number: 6,307,105

Title: High purity preparation of fluorinated 1,3-dicarbonyls using BDM(bis-fluroxy difluoromethane)

Abstract: A process for providing an .alpha.-fluorinated-.beta.-dicarbonyl includeselectrophilically fluorinating a .beta.-dicarbonyl withbis-fluoroxydifluoromethane in the presence of an acid to provide the.alpha.-monofluorinated-.beta.-dicarbonyl. The acid is preferablyhydrofluoric acid. Preferred .beta.-dicarbonyls includemethyl-3-oxopentanoate and ethyl-4,4,4-trifluoroacetoacetate. The processcan limit radical impurity byproducts to no more than 4% in some cases,and less than 0.5% in other cases. Theoretical yields of 95%.alpha.-monofluorinated-.beta.-dicarbonyl are possible in some cases.

Inventors: Casteel, Jr.; William Jack (Emmaus, PA), Syvret; Robert George (Allentown, PA), Bailey, III; Wade Hampton (Emmaus, PA)


International Classification:

Expiration Date: 10/23/2013