Patent Number: 6,309,549

Title: Polynucleotide separations on polymeric separation

Abstract: Non-polar polymeric separation media, such as beads or monoliths, are suitable for chromatographic separation of mixtures of polynucleotides when the surfaces of the media are unsubstituted or substituted with a hydrocarbon group having from one to 1,000,000 carbons and when the surfaces are substantially free from mutivalent cation contamination. The polymeric media provide efficient separation of polynucleotides using Matched Ion Polynucleotide Chromatography. Methods for maintaining and storing the polymeric media include treatment with multivalent cation binding agents.

Inventors: Gjerde; Douglas T. (Saratoga, CA), Taylor; Paul D. (Palo Alto, CA), Haefele; Robert M. (Palo Alto, CA)

Assignee: Transgenomic, Inc.

International Classification: B01D 15/08 (20060101); B01D 015/08 ()

Expiration Date: 10/30/2018