Patent Number: 6,309,569

Title: Encapsulation of bioactive agents

Abstract: Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)-in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5dl/g, and methods for their preparation. DNA release is modified through use of low i.v. PLG. A particle production method for scale-up uses a blender that avoids excessive shear damage to DNA being encapsulated.

Inventors: Farrar; Graham Henry (Salisbury, GB), Tinsley-Bown; Anne Margaret (Salisbury, GB), Jones; David Hugh (Montreal, CA)

Assignee: Microbiological Research Authority

International Classification: A61K 9/16 (20060101); A61K 9/00 (20060101); B01J 013/02 (); B01J 013/04 (); B01J 013/20 (); B05D 007/00 ()

Expiration Date: 10/30/2018