Patent Number: 6,309,623

Title: Stabilized preparations for use in metered dose inhalers

Abstract: Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.

Inventors: Weers; Jeffry G. (San Diego, CA), Schutt; Ernest G. (San Diego, CA), Dellamary; Luis A. (San Marcos, CA), Tarara; Thomas E. (San Diego, CA), Kabalnov; Alexey (Corvallis, OR)

Assignee: Inhale Therapeutic Systems, Inc.

International Classification: A61K 9/16 (20060101); A61K 9/00 (20060101); A61K 009/12 ()

Expiration Date: 10/30/2018