Patent Number: 6,309,636

Title: Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods ofuse thereof, and methods of humanizing antibody peptides

Abstract: The present invention provides recombinant peptides that specifically andselectively bind to the human milk fat globule (HMFG) antigen, BA46. Inparticular, the present invention provides recombinant variants of the Mc3antibody, including humanized versions of Mc3. The variant Mc3 peptidesare particularly useful for diagnostic, prognostic, and therapeuticapplications in the field of breast cancer.The present invention also provides methods for the humanization ofantibodies such as murine monoclonal antibodies. The novel humanizationmethods are applied to the production of humanized Mc3 antibodies and itis shown that these humanized antibodies retain the ability to engage inhigh affinity binding to their cognate antigen. Such humanization enablesthe use of these antibodies for immunodiagnostic and immunotherapeuticapplications in humans.

Inventors: do Couto; Fernando J. R. (Pleasanton, CA), Ceriani; Roberto L. (Lafayette, CA), Peterson; Jerry A. (San Francisco, CA)


International Classification:

Expiration Date: 10/32013