Patent Number: 6,309,639

Title: Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand

Abstract: P-selectin has been demonstrated to bind primarily to a single major glycoprotein ligand on neutrophils and HL-60 cells, when assessed by blotting assays and by affinity chromatography of [.sup.3 H]glucosamine-labeled HL-60 cell extracts on immobilized P-selectin. This molecule was characterized and distinguished from other well-characterized neutrophil membrane proteins with similar apparent molecular mass. The purified ligand, or fragments thereof (including both the carbohydrate and protein components), or antibodies to the ligand, or fragments thereof, can be used as inhibitors of binding of P-selectin to cells.

Inventors: Cummings; Richard D. (Edmond, OK), Moore; Kevin L. (Oklahoma City, OK), McEver; Rodger P. (Oklahoma City, OK)

Assignee: The Board of Regents of the University of Oklahoma

International Classification: C07K 14/435 (20060101); C07K 16/28 (20060101); C07K 14/705 (20060101); C07K 16/18 (20060101); A61K 38/00 (20060101); A61K 039/395 (); C07K 016/28 ()

Expiration Date: 10/30/2018