Patent Number: 6,309,645

Title: MHC molecules and uses thereof

Abstract: The present invention relates to novel complexes of major histocomability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

Inventors: Rhode; Peter R. (Miami, FL), Jiao; Jin-An (Fort Lauderdale, FL), Burkhardt; Martin (Miami, FL), Wong; Hing C. (Fort Lauderdale, FL)

Assignee: Sunol Molecular Corporation

International Classification: C07K 14/74 (20060101); C07K 14/435 (20060101); A61K 38/00 (20060101); A61K 039/00 (); C12P 021/04 (); C07K 014/00 (); C07K 016/00 ()

Expiration Date: 10/30/2018