Patent Number: 6,309,649

Title: Subunit respiratory syncytial virus vaccine preparation

Abstract: The fusion (F) protein, attachment (G) protein and matrix (M) protein ofrespiratory syncytial virus (RSV) are isolated and purified fromrespiratory syncytial virus by mild detergent extraction of the proteinsfrom concentrated virus, loading the protein onto a hydroxyapatite orother ion-exchange matrix column and eluting the protein using mild salttreatment. The F, G and M proteins, formulated as immunogeniccompositions, are safe and highly immunogenic and protect relevant animalmodels against decreased caused by respiratory syncytial virus infection.

Inventors: Cates; George A. (Richmond Hill, CA), Sanhueza; Sonia E. (Willowdale, CA), Oomen; Raymond P. (Schomberg, CA), Klein; Michel H. (Willowdale, CA)


International Classification:

Expiration Date: 10/32013