Patent Number: 6,309,665

Title: Composition with sustained release of active principle, capable of forming a microemulsion

Abstract: The invention concerns a composition comprising a microemulsion forming system by contact with a hydrophilic phase brought, after ingestion, by the physiological fluid, said microemulsion forming system comprising: at least an active principle; a lipophilic phase; a surfactant (TA); a co-surfactant (CoTA). The invention is characterized in that said composition further comprises an inert polymeric matrix which cannot be ionised at physiological pH, dispersed in the microemulsion forming system before ingestion, said polymeric matrix being capable, after ingestion, of forming on contacting the physiological fluid, a gelled polymeric matrix enabling to release by diffusion, in continuous and prolonged manner the already micro-emulsified active principle.

Inventors: Barthelemy; Philippe (Mions, FR), Benameur; Hassan (Genas-Azieu, FR)

Assignee: Gattefosse S.A.

International Classification: A61K 9/107 (20060101); A61K 9/48 (20060101); A61K 009/66 ()

Expiration Date: 10/30/2018