Patent Number: 6,309,666

Title: Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract

Abstract: A pharmaceutical preparation in the form of a coated capsule which can release contents of a capsule at a lower part of the digestive tract comprising (a) a hard capsule containing at least an acidic substance, (b) a polymer film soluble at low pH which is formed on a surface of said hard capsule, and (c) an enteric coating film which is formed on a surface of said polymer film soluble at low pH. According to the pharmaceutical preparation of the present invention, any kind of a medicament can be delivered to any desired site between the upper part of the small intestine and the lower part of the large intestine in the digestive tract by controlling the amount of polymer(s) used for the polymer film soluble at low pH and/or by selecting the kind of the polymer film soluble at low pH and/or the acidic substance without any complicated requirements for each medicament.

Inventors: Hatano; Harumi (Amagasaki, JP), Ito; Takahiro (Yao, JP), Ishibashi; Takashi (Sakai, JP), Yoshino; Hiroyuki (Suita, JP), Mizobe; Masakazu (Takatsuki, JP)

Assignee: Tanabe Seiyaku Co., Ltd.

International Classification: A61K 9/48 (20060101); A61K 009/52 ()

Expiration Date: 10/30/2018