Patent Number: 6,309,820

Title: Polypeptides having a functional domain of interest and methods of identifying and using same

Abstract: Novel polypeptides having functional domains of interest are described, along with DNA sequences that encode the same. A method of identifying these polypeptides by means of a sequence-independent (that is, independent of the primary sequence of the polypeptide sought), recognition unit-based functional screen is also disclosed. Various applications of the method and of the polypeptides identified are described, including their use in assay kits for drug discovery, modification, and refinement.

Inventors: Sparks; Andrew B. (Carrboro, NC), Hoffman; Noah (Greensboro, NC), Kay; Brian K. (Chapel Hill, NC), Fowlkes; Dana M. (Chapel Hill, NC), McConnell; Stephen J. (San Diego, CA)

Assignee: University of North Carolina at Chapel Hill

International Classification: C12Q 1/68 (20060101); C12N 15/10 (20060101); G01N 33/68 (20060101); A61K 38/00 (20060101); C12Q 001/68 (); G01N 033/53 (); A61K 038/00 (); C12N 007/00 ()

Expiration Date: 10/30/2018