Patent Number: 6,309,828

Title: Method and apparatus for fabricating replicate arrays of nucleic acidmolecules

Abstract: A method and apparatus for fabricating replicate arrays of nucleic acidmolecules include the preparation of the molecules and the application themolecules onto a substrate in an ordered array. The apparatus comprises asynthesis unit and a plurality of outlets. The synthesis unit comprises aplurality of synthesis chambers that are spatially arranged relative toeach other to provide an array suitable for conducting parallel nucleicacid syntheses. The chambers are suitable for containing discretecompositions of nucleic acid molecules. Each outlet of the plurality ofoutlets communicates with a single synthesis chamber. The plurality ofoutlets are configured such that nucleic acid molecules can be removedfrom the chambers through the outlet and deposited onto the substrate inan ordered array that corresponds to the spatial arrangement of thesynthesis chambers.

Inventors: Schleifer; Arthur (Portola Valley, CA), Caren; Michael P. (Palo Alto, CA), Leonard; Leslie A. (Portola Valley, CA), Hotz; Charles Z. (San Mateo, CA), Perbost; Michel G. M. (Cupertino, CA)

Assignee:

International Classification:

Expiration Date: 10/32013