Patent Number: 6,309,830

Title: Human suppressor tRNA oligonucleotides and methods of use for same

Abstract: Novel synthetic suppressor tRNA have been provided which provide read-through of internal nonsense mutations, or which can site-specifically alter translation of transcribed sequences. Uses of the same are also provided in genetic engineering protocols including gene therapy treatment of diseases such as Xeroderma pigmentosum.

Inventors: Panchal; Rekha G. (Des Moines, IA), Link, Jr.; Charles J. (Des Moines, IA)

Assignee: Human Gene Therapy Research Institute

International Classification: A61K 48/00 (20060101); C12N 15/11 (20060101); C12N 9/22 (20060101); A61K 048/00 (); C12N 015/11 (); C12Q 001/68 ()

Expiration Date: 10/30/2018