Patent Number: 6,309,842

Title: Use of modified tethers in screening compound libraries

Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.

Inventors: Dower; William J. (Menlo Park, CA), Gates; Christian M. (Santa Cruz, CA), Heinkel; Gregory L. (San Jose, CA), Lalonde; Guy (Woodside, CA), Mattheakis; Larry C. (Cupertino, CA), Paddon; Christopher J. (Pacifica, CA), Schatz; Peter J. (Mountain View, CA)

Assignee: Glaxo Wellcome Inc.

International Classification: G01N 33/543 (20060101); G01N 33/566 (20060101); G01N 33/532 (20060101); C07B 61/00 (20060101); G01N 033/53 (); G01N 033/543 ()

Expiration Date: 10/30/2018