Patent Number: 6,309,847

Title: Method for detecting or monitoring the effectiveness of treatment of T cell mediated diseases

Abstract: It has been discovered that treatment of an IDDM model with the p277 auto-antigen in a tolerogenic carrier induces a shift from a TH1 T cell response to a TH2 T cell response. The efficacy of proposed vaccines for any T cell mediated disease can be detected or monitored by measuring for such a TH1.fwdarw.TH2 T cell reponse shift.

Inventors: Cohen; Irun R. (Rehovot, IL), Elias; Dana (Rehovot, IL)

Assignee: Yeda Research and Development Co. Ltd.

International Classification: G01N 33/68 (20060101); G01N 33/50 (20060101); A61K 049/00 (); G01N 033/53 ()

Expiration Date: 10/30/2018