Patent Number: 6,309,850

Title: Method of detecting procarboxypeptidase A and carboxypeptidase A levels in biological fluids

Abstract: Methods of measuring carboxypeptidase A levels and total carboxypeptidase A levels, wherein procarboxypeptidase A is converted to carboxypeptidase A by addition of clostripain, in a biological fluid with a carboxypeptidase A substrate, specificity of which is enhanced by addition of a carboxypeptidase A specific inhibitor are provided. In addition, methods of diagnosing acute pancreatitis by measurement of carboxypeptidase A levels and pancreatic cancer by measurement of total carboxypeptidase A levels are also provided.

Inventors: Gilvarg; Charles (Princeton, NJ)

Assignee: Princeton University

International Classification: C12Q 1/37 (20060101); G01N 33/574 (20060101); C12Q 001/37 (); C12Q 001/00 (); G01N 033/53 ()

Expiration Date: 10/30/2018