Patent Number: 6,309,854

Title: Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72

Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

Inventors: Bergsma; Derk J. (Berwyn, PA), Brooks; David P. (West Chester, PA), Gellai; Miklos (Devon, PA), Wilson; Shelagh (Hertford, GB), Yanagisawa; Masashi (Dallas, TX)

Assignee: Smithkline Beecham Corporation

International Classification: C07K 14/435 (20060101); C07K 16/18 (20060101); C07K 14/575 (20060101); C07K 16/26 (20060101); A61K 38/00 (20060101); C07H 021/04 (); C12P 021/06 (); C12N 015/00 ()

Expiration Date: 10/30/2018