Patent Number: 6,309,855

Title: Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs

Abstract: This invention relates to a new member of a recently recognized TWIK potassium.sup.+ channel family, herein identified as TASK, for TWIK-related acid-sensitive K.sup.+ channel. This is the first cloned mammalian channel that produces K.sup.+ currents that possesses all the characteristics of background conductances. The invention also relates to various constructs including the TASK or related human potassium channel family, and their uses.

Inventors: Duprat; Fabrice (Vallauris, FR), Lesage; Florian (Paris, FR), Fink; Michel (La Bocca, FR), Lazdunski; Michel (Nice, FR)

Assignee: Centre National de la Recherche (CNRS)

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); A61K 38/00 (20060101); C12P 021/06 (); C12N 015/00 (); C12N 015/63 (); C07H 021/02 ()

Expiration Date: 10/30/2018