Patent Number: 6,309,858

Title: T-type calcium channel variants; compositions thereof; and uses

Abstract: The invention provides TCCV-1 or TCCV-2 from human, reagents related thereto including polynucleotides encoding TCCV-1 or TCCV-2, purified polypeptides, and specific antibodies. Methods of making and using these reagents, in particular, methods for screening compounds which modulate TCCV-1 or TCCV-2 activity are provided. Also provided are methods of diagnosis and kits.

Inventors: Dietrich; Paul Shartzer (Palo Alto, CA), McGivern; Joseph Gerard (Mountain View, CA)

Assignee: Syntex (U.S.A.) LLC

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C12P 021/02 (); C12N 005/00 (); C12N 015/00 (); C07H 021/02 (); C07H 021/04 ()

Expiration Date: 10/30/2018