Patent Number: 6,309,859

Title: Method for removing N-terminal methionine

Abstract: The present invention provides a method for chemically removing aN-terminal methionine residue selectively, specifically and efficientlyfrom a peptide or a salt thereof having an optionally oxidized methinineresidue at its N-terminal. The method reacts a peptide or a salt thereofhaving an optionally oxidized methinine residue at its N-terminal with an.alpha.-diketone derivative, followed by hydrolysis.

Inventors: Nishimura; Osamu (Hyogo, JP), Suenaga; Masato (Hyogo, JP), Ohmae; Hiroaki (Nara, JP), Tsuji; Shinji (Hyogo, JP)


International Classification:

Expiration Date: 10/32013