Patent Number: 6,309,860

Title: Cloning and uses of BCL-8

Abstract: This invention provides an isolated nucleic acid which encodes bcl-8. Thisinvention also provides an oligonucleotide of at least 15 nucleotidescapable of specifically hybridizing with a sequence of nucleotides withina nucleic acid which encodes bcl-8. Further, this invention provides anagent capable of blocking the expression of BCL-8. This invention alsoprovides various methods of determining whether a subject is afflictedwith diffuse large cell lymphoma. This invention further provides a methodof determining whether a subject has a predisposition for diffuse largecell lymphoma. This invention further provides various methods of treatinga subject afflicted with diffuse large cell lymphoma. This invention alsoprovides various methods of preventing diffuse large cell lymphoma in asubject. This invention also provides pharmaceutical compositions fortreating and/or preventing diffuse large cell lymphoma.

Inventors: Chaganti; Raju S. K. (New York, NY), Dyomin; Vadim (Tenafly, NJ), Dalla-Favera; Riccardo (New York, NY)

Assignee:

International Classification:

Expiration Date: 10/32013