Patent Number: 6,309,876

Title: Neuron promoter and uses

Abstract: The present invention relates to a DNA expression vector comprising a T.alpha.l .alpha.-tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage and the promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention to the material and detecting the expressed marker gene as an indication of neurogenesis and neuronal growth.

Inventors: Miller; Freda Diane (Montreal, CA), Gloster; Andrew (Montreal, CA), Causing; Carrie Grace (Montreal, CA), Toma; Jean George (Edmonton, CA)

Assignee: McGill University

International Classification: C07H 21/00 (20060101); C07H 21/04 (20060101); C12N 5/00 (20060101); C12N 15/00 (20060101); C12Q 1/02 (20060101); C12N 015/00 (); C12N 005/00 (); C12Q 001/02 (); C07H 021/04 ()

Expiration Date: 10/30/2018