Patent Number: 6,309,880

Title: Antibodies specific for CD4-binding domain of HIV-1

Abstract: A particular epitope located within the CD4-binding region of gpl20 of HIV-1, and antibodies specific for the epitope which can inhibit HIV-1 infection of human cells by diverse strains and isolates of the virus, is disclosed. The antibodies are useful for a number of purposes, including diagnosis of HIV-1 infection.

Inventors: Chang; Tse Wen (Houston, TX), Fung; Michael S. C. (Houston, TX), Sun; Bill N. C. (Bellaire, TX), Sun; Cecily R. Y. (Bellaire, TX), Chang; Nancy T. (Houston, TX)

Assignee: Tanox, Inc.

International Classification: A61K 47/48 (20060101); C07K 14/005 (20060101); C07K 14/16 (20060101); C07K 16/08 (20060101); C07K 16/10 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); C12N 005/06 (); C12N 005/16 (); C07K 016/00 (); C12P 021/08 ()

Expiration Date: 10/30/2018